Fig. 6: Working model of non-canonical PKCε signalling in response to excess metaphase catenation. | Nature Communications

Fig. 6: Working model of non-canonical PKCε signalling in response to excess metaphase catenation.

From: The Aurora B specificity switch is required to protect from non-disjunction at the metaphase/anaphase transition

Fig. 6

In mitosis, Aurora B switches substrate specificity in response to phosphorylation of S227 in the activation loop by a cell cycle-processed active fragment of PKCε. Here, we show that this switch protects from chromosome non-disjunction by delaying anaphase entry and promoting TopoIIα-dependent resolution.

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