Fig. 6: Working model: ALIX-syntenin-syndecan-4 couples the ESCRT-III machinery to the plasma membrane at the abscission site for efficient scission. | Nature Communications

Fig. 6: Working model: ALIX-syntenin-syndecan-4 couples the ESCRT-III machinery to the plasma membrane at the abscission site for efficient scission.

From: The Flemmingsome reveals an ESCRT-to-membrane coupling via ALIX/syntenin/syndecan-4 required for completion of cytokinesis

Fig. 6

a ESCRT-III localization at the midbody depends on its recruitment by ALIX (blue) and ESCRT-I/-II (violet), which are targeted to the midbody by MKLP1-associated CEP55 (gray). This first step does not require syntenin or syndecan-4. b ESCRT-III localization at the abscission site, located on one side of the midbody, depends on the tripartite ALIX-syntenin-syndecan-4 module. ALIX-syntenin (red), by directly coupling ESCRT-III (yellow) on the one hand and the transmembrane protein syndecan-4 (green) on the other hand is proposed to help maintain ESCRT-III polymers at the abscission site until the final cut.

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