Fig. 7: Model of tissue-specific Ubx transcriptional interactive networks.
Ubx specificity and functional diversity could be the result of tissue-specific transcriptional networks assembled at the cell-specific level but also at several layers of gene expression. From cis-regulatory module (CRMs) to mRNA processing, it may act as a transcriptional platform integrating multi-layered and inter-connected interactions (dot-lines) with multi-lineage (shadow-grey) or cell-restricted (purple) TFs, regulators of chromatin-contact (shadow brown), basal RNA-polymerase II machinery (grey, pol II), chromatin modifiers (blue) and mRNA-processing regulators (orange). Interactions are mainly formed with ubiquitously expressed proteins in a tissue-specific manner (red line) and a few lineage-restricted TFs (purple TF proteins) that might promote specific conformational changes. In the context of transcriptional micro-environments, this might be the first layer of cell-specificity driving the assembly of higher-order interactive networks at multiple transcriptional levels in a precise spatial and temporal context. Image adapted from Carnesecchi et al.12 with permission.
