Table 1 Patient and tissue sample characteristics.

From: OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation

Patient and tissue sample characteristics

Age [a]

62.7 ± 8.0 (39.9–73.4)

PSA (ng mL−1)

12.7 ± 27.2 (2.0–181.6)

fPSA (%)

14.3 ± 5.8 (3.6–28.1)

Prostate weight (g)

44 ± 14 (20–79)

Pathological stage, N (%)

pT2 (localized)

25 (50.0)

pT3 (extracapsular extension)

21 (42.0)

pT4 (invasion into adjacent structures)

4 (8.0)

Tumor histology PCa tissue samples, N (%)

Gleason score 6 (patterns 3 + 3)

11 (22.0)

Gleason score 7 (patterns 3 + 4)

9 (18.0)

Gleason score 7 (patterns 4 + 3)

21 (42.0)

Gleason score 8 (patterns 5 + 3)

1 (2.0)

Gleason score 9 (patterns 4 + 5)

6 (12.0)

Gleason score 10 (patterns 5 + 5)

2 (4.0)

Tissue sample wet mass (mg)

Benign

6.49 ± 1.48

Malignant

6.51 ± 1.46

  1. Paired malignant and non-malignant tissue biopsy samples were extracted from the radical prostatectomy specimens by an experienced uropathologist. Age, total serum prostate specific antigen (PSA) and percentage of free PSA (fPSA) at the time of tumor diagnosis. Tissue biopsy wet mass used in high-resolution respirometry (HRR) was determined prior to the transfer of permeabilized tissue samples into the O2k chambers. Tumor histology characteristics of radical prostatectomy specimens (Gleason scores of tissue samples and pathological stages) were determined using routine histopathological procedures. Data represent mean ± SD, median (age), range or quantity and percentage, respectively.
Back to article page