Table 2 Metagene signature of severe respiratory phenotype tumors.

From: OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation

Severe respiratory phenotype metagenes

Gene ID

Gene name

ACADL

Acyl-CoA dehydrogenase long chain

ALDH7A1

Aldehyde dehydrogenase 7 family member A1

AUH

AU RNA binding methylglutaconyl-CoA hydratase

BPHL

Biphenyl hydrolase like

CHDH

Choline dehydrogenase

CRLS1

Cardiolipin synthase 1

FECH

Ferrochelatase

LDHD

Lactate dehydrogenase D

MAOA

Monoamine oxidase A

MIPEP

Mitochondrial intermediate peptidase

NUDT8

Nudix hydrolase 8

  1. Significantly overexpressed genes exhibiting a significant correlation (r > 0.4, p < 0.05, multiple t-test followed by Benjamini–Hochberg correction for multiple testing) were extracted from the “severe” phenotype samples and classified as representative “metagenes” for this phenotype.
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