Fig. 1: Structures of AAR and AAR–ADO complex.
a Cartoon (left) and surface (right) representation of AARapo structure. NTD, mid-domain, and CTD of AAR are shown in slate, yellow and magenta, respectively. The dinucleotide recognition loop in the mid-domain is highlighted in green. The key residue C294 is shown in stick-ball mode and labeled. The cleft above the residue C294 was indicated by an arrow in the right panel. b Cartoon representation of AAR–ADO complex structure (shown by AARNADPH–ADO structure). NTD, mid-domain, and CTD of AAR are shown in slate, yellow and magenta, respectively. ADO is shown in cyan and the eight helices are labeled as 1–8. The two iron atoms in ADO are shown in orange spheres. The residues involved in the intermolecular interaction are shown in sticks. The salt bridges and hydrogen bonds are shown by black dashed lines. The bound ligands are omitted for clarity. c Details of the intermolecular interaction between AAR and ADO. For clarity, only fragments of AAR (R73–H91 and L114–L122) and ADO (helix 7) are shown. The residues involved in the intermolecular interactions are shown in sticks and labeled.
