Fig. 2: AARthioester–ADO structure.
a Chemical structure of the substrate stearoyl-CoA. The red dashed line indicates the thioester bond between stearic chain and CoA moiety. b Surface representation of AARthioester–ADO structure. The L-shaped channel within AAR is indicated. The stearic chain (shown as magenta stick), covalently bound with C294 (shown in stick-ball mode), is located in the hydrophobic tunnel, which is a part of the L-shaped channel. Residues Y23 and Y26 from AAR, and M221 from ADO, forming the terminal end of the tunnel, are shown in stick and labeled. The color code of AAR and ADO is the same as that in Fig. 1b. c The hydrophobic residues, mainly from the NTD and the CTD, are involved in the substrate tunnel formation and shown as sticks. The color code of AAR is the same as that in Fig. 1b, and ADO is shown in green.
