Fig. 7: Olfaction regulates lipid metabolism through neuroendocrine signaling mechanisms.
Between two asymmetric AWC olfactory neurons, only AWCON regulates peripheral lipid metabolism. In response to specific environmental odors, this olfactory neuron signals through a specific downstream neural circuit and neuroendocrine signaling pathway (conserved components in mammals are indicated) to directly control lipid homeostasis in peripheral metabolic tissues. DCV, dense core vesicles.
