Fig. 1: Methods for introduction of deuterium into organic molecules and drug candidates. | Nature Communications

Fig. 1: Methods for introduction of deuterium into organic molecules and drug candidates.

From: Bringing biocatalytic deuteration into the toolbox of asymmetric isotopic labelling techniques

Fig. 1

State-of-the-art approaches for carbon–hydrogen or carbon–halogen hydrogen isotope exchange; these methods use either 2H2 or 2H2O as the deuterium source. The biocatalytic reductive deuteration strategy demonstrated in this work uses 2H2O as the deuterium source and H2 as a clean reductant.

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