Fig. 4: Scalable biocatalytic deuteration for preparation of heavy solifenacin fumarate.
From: Bringing biocatalytic deuteration into the toolbox of asymmetric isotopic labelling techniques
a Preparation of trideuterated (R)-3-quinuclidinol via biocatalytic reductive deuteration and b incorporation into the pharmaceutical compound (1S,3′R)-solifenacin fumarate. In each case, the mass spectroscopy traces show the expected +3 shift in m/z values of the isolated product (lower plot) relative to their natural abundance standards (upper plot). Full experimental and analytical details are provided in Supplementary Methods.
