Table 2 Effect estimates for top GWAS SNPs by ethnicity and combined across all cohorts.

From: The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis

Locus

SNP

Risk allele

E. Asian case freq.

E. Asian control freq.

E. Asian OR (95% CI)

E. Asian P-value

European case freq.

European control freq.

European OR (95% CI)

European P-value

Combined OR (95% CI)

Combined P-value

PLA2R1

rs17831251

C

0.85

0.70

2.81 (2.48–3.17)

3.5 × 10−61

0.76

0.61

1.98 (1.81–2.17)

4.7 × 10−48

2.25 (2.09–2.42)

4.7 × 10−103

NFKB1

rs230540

C

0.43

0.35

1.24 (1.14–1.36)

1.8 × 10−6

0.35

0.32

1.25 (1.14–1.36)

7.8 × 10−7

1.25 (1.17–1.33)

3.4 × 10−12

IRF4

rs9405192

G

0.51

0.42

1.40 (1.28–1.53)

8.8 × 10−14

0.73

0.69

1.18 (1.07–1.29)

6.6 × 10−4

1.29 (1.21–1.37)

1.4 × 10−14

HLA

rs9271573

A

0.60

0.35

2.97 (2.69–3.28)

3.7 × 10−102

0.62

0.44

2.06 (1.89–2.25)

1.8 × 10−60

2.41 (2.26–2.57)

2.7 × 10−154

Back to article page