Table 2 Unidimensional, age-adjusted, multi-group model.

From: Noradrenergic-dependent functions are associated with age-related locus coeruleus signal intensity differences

Group

Path

Standardized regression estimates

Overall

Rostral

Caudal

Younger

LC −> cog (^unadjusted for age)

−0.080, z = −0.995, p(>|z|) = 0.320 (^−0.164, z = −2.277, p(>|z|) = 0.023)**

−0.025, z = −0.322, p(>|z|) = 0.748 (^−0.109, z = −1.490, p(>|z|) = 0.136)

−0.107, z = −1.296, p(>|z|) = 0.195 (^−0.187, z = −2.616, p(>|z|) = 0.009)**

Age −> LC

0.438, z = 8.377, p(>|z|) < 0.001**

0.389, z = 7.198, p(>|z|) < 0.001**

0.439, z = 8.556, p(>|z|) < 0.001**

Age −> cog

−0.260, z = −2.357, p(>|z|) = 0.018**

−0.288, z = −2.718, p(>|z|) = 0.007**

−0.246, z = 2.216, p(>|z|) = 0.027**

Older

LC −> cog (^unadjusted for age)

0.156, z = 2.173, p(>|z|) = 0.030** (^0.216, z = 2.784, p(>|z|) = 0.005)**

0.194, z = 2.468, p(>|z|) = 0.014** (^0.261, z = 3.078, p(>|z|) = 0.002)**

0.112, z = 1.708, p(>|z|) = 0.088 (^0.160, z = 2.200, p(>|z|) = 0.028)**

Age −> LC

−0.087, z = −1.516, p(>|z|) = 0.129

−0.102, z = −1.771, p(>|z|) = 0.077

−0.068, z = −1.153, p(>|z|) = 0.249

Age −> cog

−0.508, z = −5.429, p(>|z|) < 0.001**

−0.501, z = −5.361, p(>|z|) < 0.001**

−0.515, z = −5.492, p(>|z|) < 0.001**

  1. LC mean normalized LC signal intensity (LC CR), Cog single latent factor.
  2. Regression path estimates between LC CR, the single latent factor, and age for younger and older age groups are shown (age-unadjusted estimates indicated by (^)). Factor loadings were constrained to be equal across the two groups. Rostral and caudal analyses were exploratory and not a pre-registered step. The number of observations was N = 605 (269 in the older and 336 in the younger group). The z-values represent the Wald statistic (obtained by dividing the parameter value by its standard error), and the p(>|z|) values test the null hypothesis that the parameter equals zero in the population (a two-sided test). Statistically significant (p(>|z|) < 0.05) values are indicated by (**). No additional adjustments were made for multiple comparisons. Source data are provided as a Source Data file.
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