Fig. 3: Manhattan plot of the 25OHD GWAS in the UK Biobank.
From: Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration
Manhattan plot showing the −log10 P-values from the fastGWA62 association test of 25-hydroxyvitamin D (25OHD) with genome-wide SNPs. Red dots represent independent variants identified as genome-wide significant with conditional and joint analysis (COJO18) applied to the GWAS summary statistics. The horizontal axis shows each chromosome, with 23 representing the X chromosome. The vertical axis is restricted to −log10 P-values < 150. Five COJO SNPs were associated at P < 1 × 10−150 (four on chromosome 11 and one on chromosome 4; Supplementary Data 3) and have approximate locations represented by three red triangles at the top edge of the plot.
