Fig. 4: Summary of selected variants associated with 25OHD in the UK Biobank.
From: Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration
Top panel shows loci associated with skin integrity, lipid and lipoprotein pathways and CYP450 and steroid-associated enzymes. Lower panel shows selected variants and putative mechanisms related to 25-hydroxyvitamin D (25OHD) concentration. For selected inter-genic loci, the nearest (upstream or downstream) gene is shown in brackets. The distance between the loci and the nearest gene is shown in base pairs. *CYP24A1 was also the closest gene for an additional three inter-genic loci with distances between 32,865–55,282 base pairs. ns non-synonymous variant, x2 or x3 two or three loci found within the gene. We note that nearest gene annotation should be interpreted recognising that these are not proof of a causal relationship between the associated SNP and expression of the gene (none-the-less supporting evidence for causal relationships is given by the SMR analyses for some loci).
