Fig. 2: Population-wide Polygenic Scores (PS) and ancestry specific partial PS. | Nature Communications

Fig. 2: Population-wide Polygenic Scores (PS) and ancestry specific partial PS.

From: Ancestry deconvolution and partial polygenic score can improve susceptibility predictions in recently admixed individuals

Fig. 2

PS distributions for seven reference populations (pastel colors), three admixed populations (yellow) and their relative ancestry specific partial PS (red and blue). Reference population medians are represented with dashed lines. The width of the boxplots is proportional to the median size of the ancestry fraction used to compute each aspPS. Four different PS for different phenotypes are shown: (a) T2D28, (b) breast cancer30 (c) height29, (d) BMI29. Significant differences with randomly assigned ancestral components are encoded as: *: p ≤ 0.05, **: p ≤ 0.005, ***: p ≤ 10−5, (one-sided Wilcoxon signed-rank test). Sample sizes and exact P-values are reported in Supplementary Data 1. For each distribution, the box represent the interquartile range (IQR = Q3−Q1), the line across the box indicate the median, the whiskers extend to the most extreme data points within Q1−1.5IQR and Q3 + 1.5IQR, outliers are omitted. CEU: North-West Europeans from Utah; IBS: Iberians from Spain; TSI: Tuscans from Italy; CHB: Han from Beijing; YRI: Yoruba from Nigeria; LWK: Luhya from Kenya; GUMUZ: Gumuz from Ethiopia; EGYPT: Egyptians; ETHIOPIA: Amhara, Oromo, Wolayta and Ethiopian Somali from Ethiopia; ASW: African-Americans from South-West USA.

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