Fig. 3: pPS predictivity. | Nature Communications

Fig. 3: pPS predictivity.

From: Ancestry deconvolution and partial polygenic score can improve susceptibility predictions in recently admixed individuals

Fig. 3

We plugged in four trait prediction models pPS obtained with genomic subsets of variable sizes (the same resulting from local ancestry analysis in our admixed individuals), in a non-admixed sample set derived from EstBB. Each point represents the performance of a different subset of the genome, applied to all individuals in the population; on the horizontal axis is reported the fraction of genomic SNPs included in each subset, while the vertical axis represents its predictivity, expressed in R2 (for binary traits we used Nagelkerke R2). Red dots represent pPS not significantly improving the base model without PS (p > 0.05, likelihood ratio test). The dashed line represents the total PS predictivity. (a) Type 2 diabetes, (b) breast cancer, (c) height, (d) BMI.

Back to article page