Fig. 9: S. aureus and E. coli proteomic response to nanopillar surface NW-850-5. | Nature Communications

Fig. 9: S. aureus and E. coli proteomic response to nanopillar surface NW-850-5.

From: Antibacterial effects of nanopillar surfaces are mediated by cell impedance, penetration and induction of oxidative stress

Fig. 9

The predicated functional partners among S. aureus a and E. coli b DEPs are shown, where individual proteins are represented in circles (nodes), and protein–protein interactions (PPI) are represented by the connecting lines (edges). DEPs have been coloured according to the log2 fold change in protein abundance (pink = decreased abundance and blue = increased abundance), and node colour indicates the confidence of supporting interaction evidence (0.15 = low confidence, 0.40 = medium confidence, 0.70 = high confidence and 0.9 = highest confidence). For S. aureus, 60 DEPs displayed at least one interaction at a confidence level between 0.46 and 1.00, and the PPI enrichment P-value was 1.0e−16. For E. coli, six proteins had at least one interaction at a medium to high confidence and had a PPI enrichment P-value of 9.54e−06. PPI enrichment P-values were determined using a hypergeometric test and corrected for multiple testing using the method of Benjamini and Hochber54. Data are representative of one experimental replicate, performed in triplicate.

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