Fig. 7: Mettl3 deficiency in BAT decreases energy expenditure and impairs cold tolerance.
From: METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice
a The Mettl3 mRNA levels in iBATs of WT mice after acute cold exposure for 6 h (22 °C, n = 8; 4 °C; n = 7). b, c The O2 consumption rates in 8-week-old Mettl3flox/flox and BKO mice at 22 °C (n = 5–6 for each group). d, e The CO2 production rates in 8-week-old Mettl3flox/flox and BKO mice at 22 °C (n = 5–6 for each group). f The rectal temperature of 8-week-old Mettl3flox/flox and BKO mice during acute cold exposure (4 °C) (Mettl3flox/flox, n = 10; BKO, n = 9). g Serum FFAs levels of 8-week-old Mettl3flox/flox and BKO mice housed at room temperature or after cold exposure (4 °C) for 6 h (22 °C Mettl3flox/flox, n = 9; 22 °C BKO, n = 8; 4 °C Mettl3flox/flox, n = 8; 4 °C BKO, n = 8). Data represent the mean ± SEM. Significance was determined by unpaired two-tailed Student’s t test analysis. *p < 0.05. **p < 0.01. Source data are provided as a Source Data file.
