Fig. 9: BDNF increases the firing rate of PVHTrkB neurons projecting to the LPBN. | Nature Communications

Fig. 9: BDNF increases the firing rate of PVHTrkB neurons projecting to the LPBN.

From: TrkB-expressing paraventricular hypothalamic neurons suppress appetite through multiple neurocircuits

Fig. 9

a PVHTrkB→LPBN neurons were labeled with injection of AAV2-Ef1a-fDIO-mCherry into the PVH and AAV2retro-Ef1a-DIO-FLPo into the LPBN of Ntrk2CreER/+ mice. b, c Patch-clamp recording of an mCherry-labeled PVHTrkB→LPBN neuron. Scale bars represent 25 μm. d A representative trace showing neuronal firing before and after bath application of BDNF. e Quantification of baseline neuronal firing (Base) and neuronal firing 40 min after bath application of BDNF (BDNF). Two-tailed paired Student’s t test; *P = 0.019. Source data are provided as a Source Data file.

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