Fig. 1: TCR/CD28-activation induces cell type specific gene expression programs in CD4+ T cells. | Nature Communications

Fig. 1: TCR/CD28-activation induces cell type specific gene expression programs in CD4+ T cells.

From: Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines

Fig. 1

a Overview of the experimental design. b List of cytokine conditions. c PCA plots from the whole transcriptome (upper panel) and proteome (lower panel) of TN and TM cells. Different colors correspond to cell types and different shades to stimulation time points. PCA plots were derived using 47 naive and 47 memory T cell samples for RNAseq and 21 naive and 19 memory T cell samples for proteomics. d Gene expression changes at the RNA and protein levels by comparing TCR/CD28-activated (Th0) cells to resting cells. Up-regulated genes are in red and down-regulated genes are in blue. Different shades indicate different fold-change thresholds. e A selection of significantly enriched pathways (with enrichment scores > 0.7) from genes and proteins differentially expressed after 5 days of activation using the 1D enrichment method. Source data are provided as a Source Data file.

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