Fig. 3: Effectorness gradient in resting CD4+ T cells. | Nature Communications

Fig. 3: Effectorness gradient in resting CD4+ T cells.

From: Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines

Fig. 3

a UMAP of single-cell RNA-seq data from resting T cells. Colors represent cells in the five clusters defined using top variable genes and unsupervised clustering. Bar plots represent the proportion of cells assigned to different clusters in each biological replicate. b Gene markers of each cell cluster (Wilcoxon rank sum test) combined with well known markers from the literature. Colors encode the mean expression of each gene in each cluster. c Branched pseudotime trajectory, each cell is colored by its pseudotime value (left panel) or its cluster label (right panel), as determined in a. d Heatmap of genes variable along the pseudotime trajectory (from Monocle). The X axis represents cells ordered by pseudotime (from left to right) and different colors correspond to the scaled (Z-scored) expression of each gene in each cell. Source data are provided as a Source Data file.

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