Fig. 3: DSS-treated IL10−/− mice develop colon polyposis and dysbiosis.
From: Limiting oxidative DNA damage reduces microbe-induced colitis-associated colorectal cancer
a Four-week-old IL10+/− and IL10−/− mice were treated with 1% DSS for 1 week followed by 5 weeks of regular drinking water, and colitis development was monitored as in Fig. 1a. N = 20 mice were examined. Data are presented as mean values ± SEM. b Colon length was measured in 9-week-old mice of the indicated genotypes and treatments. N = 26 mice were examined. c Weighted UniFrac principal coordinate analysis of 16 S rRNA gene-sequencing analysis of fecal bacteria obtained from DSS-treated IL10−/− mice. Fecal samples were obtained before (day 0), 1, and 5 weeks after DSS treatment. N = 13 mice were examined. d Same as c, except that IL10+/− mice were used. N = 7 mice were examined. e Polyp number was analyzed in the colon of 9-week-old mice of the indicated genotypes and treatments. N = 26 mice were examined. Data in b and e were analyzed using the two-sided non-parametric t-test Mann–Whitney; *p < 0.05, **p < 0.01, ****p < 0.0001.
