Fig. 3: Myc binding is dictated by chromatin access.
From: Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity
a Heatmap of peaks called by DNAse treated, acetylated H3K27 (H3K27ac), tri-methylated H3K4 (H3K4me3) and RNA polymerase II (PolII) ChIP sequencing at Myc-bound promoter elements that are common between both the liver and heart (common-black), or specific for an individual tissue (liver specific—green, heart specific—red). Myc ChIP sequencing was performed on the heart and livers isolated from R26CMER/+ mice 4 h post administration of 4-OHT, overlap of n = 2. PolII ChIP sequencing performed on the heart and livers isolated from wild-type (R26+/+) mice, overlap of n = 2. ChIP sequencing data for DNase treated, H3K27ac and H3K4me3 were taken from the ENCODE Project (accession numbers; GSM1014166, GSM1000093, GSM769017, GSM1014195, GSM1000140 and GSM769014). b As in a but for distal elements.
