Fig. 7: Model for CHD3NEMO mechanism of action.
From: Modulation of virus-induced NF-κB signaling by NEMO coiled coil mimics
a vFLIP activates NF-κB by engaging NEMO. b CHD3NEMO (NEMO mimic) can directly bind vFLIP and compete with NEMO-vFLIP complex formation leading to destabilization of the IKK signalosome and inhibition of vFLIP-induced NF-κB activation in PEL cells.
