Fig. 3: Wireless optogenetics increases whole-body energy expenditure at thermoneutrality.
From: Wireless optogenetics protects against obesity via stimulation of non-canonical fat thermogenesis
a Whole-body oxygen consumption rate (VO2) of Adipo-ChR2 mice and littermate controls following optogenetics light stimulation at thermoneutrality (left). The quantification of light-stimulated VO2 is shown on the right graph. Control, n = 8; Adipo-ChR2, n = 11. b Whole-body VO2 following a single administration of β3 adrenergic receptor agonist (CL-316,243 at 0.01 mg kg−1) or vehicle (saline) at thermoneutrality. The quantification of CL-316,243 or saline-induced VO2 of wild-type mice is shown on the right. saline, n = 7; CL-316,243, n = 7. Data were analyzed by two-way repeated-measures ANOVA followed by post-hoc paired/unpaired t-test with Bonferroni’s correction (left in a–b) or unpaired two-sided t-test (right in a–b). All Data are expressed as means ± s.e.m. n.s. not significant.
