Fig. 4: Light-induced adipose tissue thermogenesis prevents diet-induced obesity.
From: Wireless optogenetics protects against obesity via stimulation of non-canonical fat thermogenesis
a Changes in body weight of Adipo-ChR2 mice and littermate controls. Control, n = 8; Adipo-ChR2, n = 10. b Food intake of Adipo-ChR2 mice and littermate control mice in a. Control, n = 8; Adipo-ChR2 n = 10. c Body composition of Adipo-ChR2 mice and littermate controls in a. Control, n = 8; Adipo-ChR2, n = 10. d Tissue-weight of adipose tissues and liver of Adipo-ChR2 mice and littermate controls in a. Control, n = 8; Adipo-ChR2, n = 10. e Representative images of hematoxylin and eosin (H&E) staining of the inguinal WAT from Adipo-ChR2 mice (lower panel) and the littermate controls (upper panel). Scale bars,100 μm. f Histogram (left panel) and quantification (right panel) of adipocyte size in the inguinal WAT in e. Control, n = 5; Adipo-ChR2, n = 5. Data were analyzed by two-way repeated-measures ANOVA followed by post hoc unpaired t-test with Bonferroni’s correction (a), unpaired two-sided t-test (b–d, and f). All data are expressed as means ± s.e.m. n.s. not significant.
