Fig. 5: Induction of partial peripheral tissue IR disruption following high-fat diet feeding lowers hepatic lipid content without impairing glucose tolerance. | Nature Communications

Fig. 5: Induction of partial peripheral tissue IR disruption following high-fat diet feeding lowers hepatic lipid content without impairing glucose tolerance.

From: Partial impairment of insulin receptor expression mimics fasting to prevent diet-induced fatty liver disease

Fig. 5

Following 8 weeks of high-fat diet (HFD) feeding, mice were treated with tamoxifen and body mass a body composition b, c, hepatic lipid content d and plasma ALAT e were determined, and glucose homeostasis assessed via glucose tolerance test f and blood glucose measurement g 6–7 weeks later. Results are shown as means ± SE, with n’s represented as individual data point’s in figures. For body weight and GTT n = 13 for WT and 9 for PerIRKO+/−. Significance was determined using two-tailed student’s t test; *p < 0.05, **p < 0.01, and ***p < 0.001 vs WT.

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