Fig. 4: Neonatal tauroursodeoxycholic acid treatment improves parasympathetic innervation in the pancreas. | Nature Communications

Fig. 4: Neonatal tauroursodeoxycholic acid treatment improves parasympathetic innervation in the pancreas.

From: The endoplasmic reticulum stress-autophagy pathway controls hypothalamic development and energy balance regulation in leptin-deficient neonates

Fig. 4

Representative images and quantification of islet size and the density of vesicular acetylcholine transporter(VAChT)-immunoreactive fibers (red) in the insulin+ islets (green) of 10- to 12-week-old wild-type (WT) mice, leptin-deficient (ob/ob) mice treated neonatally with vehicle or tauroursodeoxycholic acid (TUDCA), and ob/ob; Pomc-Cre; Atg7loxP/loxP mice treated neonatally with vehicle or TUDCA (n = 6–7 per group). Error bars represent the SEM. *P ≤ 0.05, **P < 0.01, and ****P ≤ 0.0001 versus all groups. Statistical significance was determined by one-way ANOVA followed by Tukey’s multiple comparison test. Scale bar, 100 µm. Source data are provided as a Source Data file.

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