Fig. 6: Correlation between α-syn-specific T cell reactivity and clinical variables.
From: α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease
a Age (n = 97): dotted lines indicate 250 SFC and 70-year-old cut-off for two-tailed Fisher’s exact test. b Frequency and magnitude of T cell responses in males (n = 71) and females (n = 26) with PD. The dotted line indicates 250 SFC for Fisher’s exact test. c MoCA score (n = 85), d UPDRS score (n = 85), and e LED score (n = 86); dotted lines indicate 250 SFC and 1000 LED cut-off for two-tailed Fisher’s exact test. f Correlation between LED score and time since diagnosis (n = 86); dotted lines indicate 10 years since diagnosis and 1000 LED cut-off for two-tailed Fisher’s exact test. Correlation is indicated by Spearman r and associated p value. g Segregation of subjects with PD in low (<1000) and high (≥1000) LED score with diagnosis <10 and ≥10 years ago. Number of data points per condition is indicated in the figure (Total No.). Two-tailed Fisher’s exact test comparing individuals with <1000 LED, <10 years ago since diagnosis and >250 SFC (left in graph) vs. the three other groups. h Segregation of subjects with PD based on LED score (cut-off 1000), years since diagnosis (cut-off 10) and age (cut-off 70). Two-tailed Fisher’s exact test comparing individuals with <1000 LED, <10 years ago since diagnosis, >70 years old, and >250 SFC (left in graph) vs. the seven other groups. Total number of PD responding to α-syn peptide pool (n = 28). Total SFC is defined as the magnitude of responses (sum of IFNγ, IL-5, and IL-10) against the α-syn peptide pool as SFC per 106 cultured PBMC. b, g, h Median ± interquartile range is indicated.
