Fig. 1: A brief description on the data sets. | Nature Communications

Fig. 1: A brief description on the data sets.

From: A double-hit of stress and low-grade inflammation on functional brain network mediates posttraumatic stress symptoms

Fig. 1

Two large independent data sets were used in this study. a Seven hundred adults in data set 1 were categorized into one of two groups based on serum levels of IL-6, IL-1β, and TNF-α. This was used to determine whether inter-network connectivity strength may be altered in relation to low-grade inflammation. b Data set 2 included 52 subjects with repeated exposure to traumatic events and 46 demographically matched healthy individuals without having been exposed to any traumatic event, and were further categorized according to their levels of low-grade inflammation. Alterations in inter-network connectivity strength in relation to both conditions of low-grade inflammation and stress exposure were examined using data set 2 shown in panel b. Furthermore, data from the stress-exposed group (n = 52) of data set 2 were also used to examine whether alteration in inter-network connectivity strength may contribute to PTS symptom severity. IL-6 interleukin-6, IL-1β interleukin-1β, TNF-α tumor necrosis factor-α, PTS posttraumatic stress.

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