Fig. 10: Conditionally blocking Wnt secretion from neonatal astrocytes reduces HIFα-regulated CNS angiogenesis in the early postnatal CNS.
From: Glial type specific regulation of CNS angiogenesis by HIFα-activated different signaling pathways
a Representative confocal images of Laminin and IB4 in the cerebral cortex of each group of mice at P8 that had been treated with tamoxifen at P1, P2, and P3. b Percentage of Laminin-occupying area among the total area at P8. Cortex, one-way ANOVA followed by Tukey’s multiple comparisons, *P < 0.05, ***P < 0.001, F(2,12) = 41.00, P < 0.0001. Spinal cord, Welch’s ANOVA followed by unpaired t test with Welch’s correction, *P < 0.05, **P < 0.01 W(2,6.824) = 11.42, P = 0.0067. n = 6 Ctrl, 6 VHL cKO, 3 VHL/Wls cKO. c Representative confocal images of ERG and IB4 in the P8 cerebral cortex of each group of mice that had been treated with tamoxifen at P1, P2, and P3. d Density (#/mm2) of ERG+ ECs at P8. One-way ANOVA followed by Tukey’s multiple comparisons, **P < 0.01, ***P < 0.001. F(2,12) = 92.24, P < 0.0001 cortex, F(2,12) = 24.37, P < 0.0001 spinal cord. n = 6 Ctrl, 6 VHL cKO, 3 VHL/Wls cKO. Data are shown as mean ± s.d. Source data of b, d are provided as a Source Data file.
