Fig. 3: Genome mining and design of DDP pathways. | Nature Communications

Fig. 3: Genome mining and design of DDP pathways.

From: Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones

Fig. 3

a Biosynthetic pathway for common intermediate 4. b DDP biosynthetic gene clusters distributed in five fungal genera. c Comparative analysis of each biosynthetic gene cluster. d Design of native pathways, extended steps and one shunt pathway heterologously reconstituted in this study and summary of products (red numbers show compounds that have not been reported.) produced through the DDP pathways (blue square, green square, red square and black square show intermediates, end products, additionally modified products and shunt products, respectively).

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