Fig. 6: Biological activity against Drosophila.

a Inhibitory effect of compound 21 on the IMD pathway Drosophila l(2)mbn cells were stimulated with heat-killed E. coli and the activity of the Attacin promoter, a read-out of the activation of the IMD pathway, was monitored by a luciferase assay. Data are means ± SEM of triplicate wells from a single experiment and are representative of two independent experiments. b Toxic effect of compound 5 on Drosophila adult. Adult flies (c.a. 1 mg each) were injected with the indicated compounds (3.5 ng each), and the flies that did not show movement or only faint shaking of their legs were counted as unmoving flies. Data are the means ± SEM of triplicate samples from a single experiment and are representative of two independent experiments. Source data underlying Fig. 6a, b are provided in a Source Data file.