Fig. 7: Inhibitory activity of Aβ aggregation. | Nature Communications

Fig. 7: Inhibitory activity of Aβ aggregation.

From: Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones

Fig. 7

a Selected results of the Th-T assay (n = 3). b TEM analysis of typical amyloid fibrils formed by Aβ42. Scale bar =  100 nm. Representative micrographs are selected from at least six micrographs taken in one grid. c Hypothetical reaction mechanism of 13 and lysine derivative 28 (13 was reacted with 28 (5.0 eq) in THF at r.t. for 10 h to give adducts 26 and 27). Source data underlying Fig. 7a, b are provided in a Source Data file.

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