Fig. 4: The resistance of all mutants to PIP, ATM, and FEP when co-applied with AVI as calculated from high-throughput sequencing data. | Nature Communications

Fig. 4: The resistance of all mutants to PIP, ATM, and FEP when co-applied with AVI as calculated from high-throughput sequencing data.

From: Escape mutations circumvent a tradeoff between resistance to a beta-lactam and resistance to a beta-lactamase inhibitor

Fig. 4

The relative resistance of all identified mutants to the beta-lactam drugs when supplemented with 0.25 μg/ml avibactam calculated as the drug concentration that inhibits mutant growth, \({\mathrm{IC}}50_{{\mathrm{AB}}}^{{\mathrm{Mut}}}|^{{\mathrm{AVI}}}\), divided by that of the WT \({\mathrm{IC}}50_{{\mathrm{AB}}}^{{\mathrm{WT}}}|^{{\mathrm{AVI}}}\). The WT amino acid is marked with an X and mutations, which were not included in our design are marked in gray. Mutations which did not confer resistance to any drug were not enriched and could not be identified in our data are marked with a dot. Source data are provided as a Source Data file.

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