Fig. 6: Liver fat content and composition in groups with different metabolic disorders.
Comparisons between overweight/obese controls without NAFL (controls, n = 7 for total liver fat content, n = 6 for liver fat composition), overweight/obese with NAFL (NAFL, n = 15), patients with type 2 diabetes (T2D, n = 9) and GSD type 1a (GSD1a, n = 7). a Total liver fat content in control, NAFL, T2D, and GSD1a. Total liver fat content was significantly higher in the NAFL group compared to the control group (p = 0.002) and in the GSD1a group compared to the control group (p = 0.027). b SFA fraction in control, NAFL, T2D, and GSD1a. SFA fraction was significantly higher in the GSD1a group compared to the control group (p = 7.3 × 10−5) and NAFL group (p = 0.034), significantly higher in the T2D group compared to the control group (p = 0.016), and significantly higher in the NAFL group compared to the control group (p = 0.022). c MUFA fraction in control, NAFL, T2D, and GSD1a. MUFA fraction was significantly lower in the GSD1a group compared to the control group (p = 0.006). d PUFA fraction in control, NAFL, T2D, and GSD1a. Data are presented as mean with error bars showing the SEM. Different letters indicate significant differences between groups (Kruskal–Wallis, p < 0.05 for IHL and PUFA, and one-way ANOVA, p < 0.05 for SFA and MUFA). Bonferroni correction was used for post-hoc analyses.
