Fig. 1: The prevalence of sSR-A in patients with RA.

a–c The serum levels of sSR-A were significantly higher in patients with RA than those of healthy individuals and patients with other common rheumatic diseases and non-autoimmune inflammatory diseases. a patients with other common rheumatic diseases (systemic lupus erythematosus (SLE, ***p = 1.1346E−10), Sjogren’s Syndrome (SS, ***p < 1E−15), ankylosing spondylitis (AS, ***p = 1.1289E−08), Gout (**p = 0.0035), psoriatic arthritis (PsA, ***p = 1.3426E−04), ANCA-associated vasculitis (AAV, ***p = 2.0262E−07), adult onset still’s disease (AOSD, ***p = 2.98E−13), polymyalgia rheumatic (PMR, ***p = 8.2141E−06), and osteoarthritis (OA, ***p = 2E−15)) and healthy controls (***p = 4E−15); b patients with autoimmune hepatitis (AIH, ***p = 7.8003E−04) and healthy controls (***p < 1E−15); c patients with non-autoimmune inflammatory diseases (NAID, including enteritis, gastritis, pneumonia, and colitis, ***p < 1E−15) and healthy controls (***p = 3.8E−14). d sSR-A were higher in SLE or SS overlapped with RA patients than SLE overlapped with SS patients (***p = 9.8292E−10), SLE patients (***p = 3.1014E−07) and SS patients (***p = 1.9579E−11). RA = 107; SLE = 30; SS = 30; AS = 39; Gout = 39; PsA = 39; AAV = 39; AOSD = 30; PMR = 24; OA = 20; HC = 90; AIH = 25; NAID = 71; SLE or SS overlapped with RA = 98; SLE overlapped with SS = 31. Red horizontal lines: means; error bars: SEMs. **p < 0.01, ***p < 0.001 (Kruskal–Wallis test followed by Dunn’s posttest for multiple comparisons). Source data are provided as a Source Data file.