Table 1 Sensitivity and specificity of sSR-A in RA diagnosis.

From: Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study

Cohorts

Groups

N

Positive (n)

Sensitivity (%)

Specificity (%)

PPV (%)

NPV (%)

Beijing cohort (training cohort)

RA

528

324

61.36

94.38

86.17

81.08

SLE

254

31

12.20

–

–

–

SS

120

11

9.17

–

–

–

OA

72

5

6.94

–

–

–

HC

480

5

1.04

–

–

–

Inner Mongolia cohort (validation cohort 1)

RA

213

156

73.24

90.51

75.73

89.33

SLE

144

19

13.19

–

–

–

SS

144

26

18.06

–

–

–

OA

119

3

2.52

–

–

–

HC

120

2

1.67

–

–

–

Hangzhou cohort (validation cohort 2)

RA

155

115

74.19

83.15

71.88

84.73

SLE

80

13

16.25

–

–

–

SS

55

23

41.82

–

–

–

OA

32

7

21.88

–

–

–

HC

100

2

2.00

–

–

–

Pooled three cohorts

RA

896

595

66.41

91.45

80.19

83.94

SLE

478

63

13.18

–

–

–

SS

319

60

18.81

–

–

–

OA

223

15

6.73

–

–

–

HC

700

9

1.29

–

–

–

  1. The cut-off value of sSR-A was established 3 SD above the mean value of healthy controls. The sensitivity and specificity of sSR-A for identification of RA were 61.36% and 94.38% in Beijing cohort, 73.24% and 90.51% in Inner Mongolia cohort, 74.19% and 83.15% in Hangzhou cohort, and 66.41% and 91.45% in the pooled three cohorts.
  2. RA rheumatoid arthritis, SLE systemic lupus erythematosus, SS Sjögren’s syndrome, OA osteoarthritis, HC healthy control, N the number of total patients, n the number of sSR-A positive patients, PPV positive predictive value, NPV negative predictive value.
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