Fig. 2: Tau-positive probabilities recapitulate Braak staging.
From: Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease
Each brain region was divided into one of six "Braak stage" ROIs, based on which Braak stage the region first shows abnormal tau (as described in ref. 83). (Left) Each row is a subject sorted top-bottom by least to most overall tau. Each column is an Braak stage ROI, sorted left to right by most to least overall tau. Warmer colors represent higher SUVR values (top), observed tau-positive probabilities (middle) or predicted tau-positive probabilites from the best-fitting ESM (bottom). (Right) The same relationship shown in a barchart format. Error bars represent standard error of the mean. Conversion to tau-positive probabilities creates a sparse distribution of values demonstrating a progression reminiscent of the staging described in the autopsy literature.
