Fig. 1: Overview of the study design. | Nature Communications

Fig. 1: Overview of the study design.

From: Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

Fig. 1

An overview of contributing studies, single-stage discovery approach, and downstream bioinformatics and in silico annotations performed to link variants to genes, and polygenic risk score analysis to link variants to cardiovascular disease risk is illustrated. Asterisk (*) The multi-ancestry meta-analysis is our primary analysis. Previously not reported loci were identified from the multi-ancestry meta-analysis. Ancestry specific and chromosome X meta-analysis are secondary. Hash (#) For bioinformatics and in silico annotations we also included loci that reached genome-wide significance in European only meta-analysis (N = 8) and were borderline genome-wide significant in the multi-ancestry meta-analysis.

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