Fig. 4: Bubble plot of phenome-wide association analysis of European ancestry PR interval polygenic risk score. | Nature Communications

Fig. 4: Bubble plot of phenome-wide association analysis of European ancestry PR interval polygenic risk score.

From: Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

Fig. 4

The polygenic risk score was derived from the European ancestry meta-analysis. Orange circles indicate that polygenic predisposition to longer PR interval is associated with an increased risk of the condition, whereas blue circles indicate that polygenic predisposition to longer PR interval is associated with lower risk of the condition. The darkness of the color reflects the effect size (odds ratio, OR) per 1 standard deviation (s.d.) increment of the polygenic risk score from logistic regression. Sample size (N) in each regression model is provided under X-axis. Given correlation between traits, we set significance threshold at P < 3.13 × 10−3 after Bonferroni correction (P < 0.05/16; dotted line) for the analysis and also report nominal associations (P < 0.05; dashed line).

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