Fig. 5: Candidate genes in PR interval loci encoding proteins involved in cardiac muscle cytoskeleton. | Nature Communications

Fig. 5: Candidate genes in PR interval loci encoding proteins involved in cardiac muscle cytoskeleton.

From: Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

Fig. 5

Candidate genes or encoded proteins are indicated by a star symbol in the figure and are listed in Supplementary Data 3. More information about the genes is provided in Supplementary Data 18 and 19. This figure was created with BioRender. *Previously not reported locus, # genome-wide significant locus in transformed trait meta-analysis. 1Missense variant; 2Nearest gene to the lead variant; 3Gene within the region (r2 > 0.5); 4Variant(s) in the locus are associated with gene expression in left ventricle and/or right atrial appendage; 5Left ventricle best HiC locus interactor (RegulomeDB score ≤ 2); 6Animal model; 7Monogenic disease with a cardiovascular phenotype.

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