Fig. 2: Immune cytolytic activity in longitudinal melanoma biopsies. | Nature Communications

Fig. 2: Immune cytolytic activity in longitudinal melanoma biopsies.

From: Transcriptional downregulation of MHC class I and melanoma de- differentiation in resistance to PD-1 inhibition

Fig. 2

a CYT scores for the 44 PRE, 6 RES and 29 PROG melanoma biopsies. Box plots show the median and interquartile ranges, and CYT scores were compared using Kruskal-Wallis with Dunn’s multiple comparison test. Dotted line aligns with the lowest RES tumor CYT score. n.s, not significant. b CYT score, clinicopathological and response details are shown for each of the 79 melanoma biopsies with RNA sequence data derived from 55 patients. The 6 responding on PD-1 inhibitor treatment biopsies are boxed. Where patients had multiple on treatment tumor biopsies these are shown as individual colored boxes within the ‘On PD-1’ and ‘Biopsy site’ rows.

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