Fig. 2: Common polymorphisms in groups of low-cytokine-inducing M. tuberculosis clinical isolates. | Nature Communications

Fig. 2: Common polymorphisms in groups of low-cytokine-inducing M. tuberculosis clinical isolates.

From: Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic surveillance systems and modulates IL-1β production

Fig. 2

Genome-wide analysis was performed for 26 M. tuberculosis clinical isolates with known IL-1β inducing profiles in human PBMCs. a Phylogenetic tree of the isolates constructed with genome-wide SNPs and using maximum likelihood. The color gradient between dark blue (low) and dark red (high) indicates the level of IL-1β induced by each strain. b Genes with (white) or without (black) polymorphisms exclusively present in >30% of the M. tuberculosis isolates classified as low or high IL-1β inducers. c ESX-1 secretion system and associated regulators showing polymorphisms exclusively present in the low or high IL-1β inducing strains.

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