Fig. 5: Model for developmental reprogramming of Egr1 by early-life EDC exposure. | Nature Communications

Fig. 5: Model for developmental reprogramming of Egr1 by early-life EDC exposure.

From: Epigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthood

Fig. 5

Schematic illustrating programming of Egr1 during normal development (left) and reprogramming of Egr1 by early-life EDC exposure (right). Reprogramming may remain transcriptionally and phenotypically silent until triggered by a later life event, such as a dietary challenge.

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