Fig. 4: Late-stage alkenylation of natural products and derivatives.
From: Photoinduced site-selective alkenylation of alkanes and aldehydes with aryl alkenes
Isolated yields. Standard conditions unless otherwise noted. aOverall yields over three steps: (1) protection: hexamethyldisilazane (0.6 equiv.), ammonium thiocyanate (0.05 equiv.), DCM, 0 °C → RT, 12 h; (2) alkenylation: standard conditions for dehydrogenative alkenylation; (3) deprotection: tetra-n-butylammonium fluoride (1 equiv.), THF, RT, 12 h. DCM = dichloromethane. THF = tetrahydrofuran.
