Fig. 5: Parsimonious metastatic maps and three modes of metastasis in CRC.
From: Mapping the spreading routes of lymphatic metastases in human colorectal cancer
a, b Parsimonious metastatic routes for nine patients. Metastatic routes between lesions are denoted by arrows and colored according to the smallest involved subclone (see Fig. 4). For instance, in Patient_2, P2 is seeded by the red subclone in the primary tumor, thus this route is labeled in red. P3 was then seeded by the red and green subclones from P2, so this route is labeled in green, since the green subclone was smaller. Three metastatic modes were extracted from 61 metastatic events: c inter-layer sequential spread, d inter-layer skip spread, and e intra-layer spread. The metastatic network is dissected into five layers, spanning from T to P, I, C, and LM. The arrows indicate metastatic routes.
