Fig. 3: KIAA0930 rs150665432 association with lung cancer risk.
From: Protein-altering germline mutations implicate novel genes related to lung cancer development
a Stratified analyses of the association between KIAA0930 Q4X and lung cancer risk, shown by different colors. Compared to non-carriers, Q4X carriers had a significantly increased lung cancer risk with ORs being 2.59 in the discovery (P = 1.15 × 10−18, n = 27966) and 1.69 in the replication datasets (P = 0.03, n = 10248). Stratified analysis showed that Q4X carriers had an increased, consistent risk for lung cancer among females, males, smokers and non-smokers and consistent in histological subtypes. The error bars are OR ± the 95% CI values. P values were determined by logistic regression analysis adjusted by age, gender, smoking status and the principal components. Source data are provided as a Source Data file. b Distribution of KIAA0930 Q4X homozygotes. In the discovery data, all homozygotes of the mutated allele in rs150665432 were developed to lung cancer in the discovery data. Source data are provided as a Source Data file (Source Data 1, 2, and 3). Color shades indicate the histological subtypes.
