Fig. 4: The onset of lung cancer risk and biallelic two-hit events of ATM rs56009889.
From: Protein-altering germline mutations implicate novel genes related to lung cancer development
a rs56009889 affects the age of onset. The error bars are mean + the standard error of the mean (SEM). In the discovery data, the mean age of onset for lung cancer cases carrying L2307F was significantly higher than cases of non-carriers. Later age of onset was observed for overall lung cancer (n = 15830), females (n = 5810), males (n = 10019), smokers (n = 14006), LAD (n = 6329) and females (n = 2954) with LAD. In the replication data, a borderline significant difference in the age of onset was observed only in females with LAD (n = 906) and non-smoker with LAD (n = 293) though the sample size is small. P values were determined by the two sides t test without adjustment. No carrier of the T allele developed LSQ and SCLC in the replication data. b the rate of loss of heterozygosity targeting either ATM L2306F allele or synonymous variants in ATM gene. Source data are provided as a Source Data file.
