Fig. 5: Correlation between chronic stress-induced increase of prefrontal glutamate release and anxiety-like behavior in mice.
From: Identification of a prefrontal cortex-to-amygdala pathway for chronic stress-induced anxiety
a Schematic showing the experimental procedures. EPM elevated plus maze, OFT open field test. b, c Representative activity tracking in EPM (b) and OFT (c). d, e Time in open arms (d) and open-arm entries (e) during EPM. Control, n = 11 mice; CRS, n = 13 mice. f, g Time in center region (f) and total distance traveled (g) during OFT. Control, n = 12 mice; CRS, n = 14 mice. h–j Correlations between the PPR in dmPFC↔BLA PNs and open-arm time (h) and entry (i) in EPM and time in center region (j) in OFT in control and CRS mice. k–m Correlations between the PPR in dmPFC→BLA PNs and open-arm time (k) and entry (l) in EPM and time in center region (m) in OFT in control and CRS mice. For d–g, data are presented as mean ± SEM, and the statistics are shown in Supplementary Table 1. n.s., not significant; *p < 0.05, **p < 0.01. For h–m, linear regression analysis and Pearson’s correlation were performed (two tailed). Source data are provided as a Source Data file.
